Vol 118, No 2 (Supplement) 2013
Supplement abstract

Phenotypic and functional characterization of endothelial progenitor cells isolated from peripheral blood of renal cell carcinoma patients

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  • Valentina Poletto,
  • Dmitry Lim,
  • Silvia Dragoni,
  • Adele Aronica,
  • Carlo Ganini,
  • Elisa Bonetti,
  • Domenico Tafuri,
  • Marianna Paccone,
  • Mariapia Cinelli,
  • Stefania Montagnani,
  • Franco Tanzi,
  • Camillo Porta,
  • Francesco Moccia,
  • Vittorio Rosti,
  • Germano Guerra

Published 2014-01-13

How to Cite

Poletto, V., Lim, D., Dragoni, S., Aronica, A., Ganini, C., Bonetti, E., … Guerra, G. (2014). Phenotypic and functional characterization of endothelial progenitor cells isolated from peripheral blood of renal cell carcinoma patients. Italian Journal of Anatomy and Embryology, 118(2), 155. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/3832
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Abstract

Endothelial progenitor cells (EPCs) are mobilized from either bone marrow or arterial walls to restore blood perfusion to ischemic organs and establish the vascular network within growing tumors [1]. The Ca2+ machinery plays a key role in EPC activation and might serve a molecular target for novel therapies of highly angiogenic tumors, such as renal cell carcinoma (RCC) [1]. The Ca2+ toolkit is remodelled in EPCs isolated from RCC patients (RCC-EPCs) as respect to healthy donors [2]. The present study was undertaken to evaluate for the first time the functional properties of EPCs isolated from tumor patients by focusing on RCC-EPCs. We extended our analysis at microscopic level by monitoring the sub-cellular structure of RCC-EPCs relative to their Ca2+ signalling fingerprint. Our results showed a striking functional and ultrastructural difference between RCC-EPCs and their normal counterparts, which might be the basis for designing novel, more specific anti-angiogenic treatments.

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