Vol. 122, No. 1 (Supplement) 2017
Supplement abstract

An ultrastructural study of Sertoli cells inside alginate microcapsules

Published 2017-10-06


  • Sertoli cells,
  • encapsulation,
  • ultrastructure

How to Cite

Burattini, S., Burini, D., Calvitti, M., Luca, G., Arato, I., Mancuso, F., Sorci, G., & Falcieri, E. (2017). An ultrastructural study of Sertoli cells inside alginate microcapsules. Italian Journal of Anatomy and Embryology, 122(1), 36. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/1761


Sertoli cells (SeC) are the main components of the blood-testis barrier, are essential for spermatogenesis and are long known for their ability to secrete trophic, anti-inflammatory and immunomodulatory factors [1]. For these reasons, SeC have been encapsulated in sodium alginate microcapsules and then used to create an ectopic immune-privileged environment to prolong survival of co-transplanted cells or modulate the immune responses [2]. Encapsulation has represented an improvement for the use of SeC. In fact, it has been reported that inside the microcapsules SeC (SeC-MC) act as a “micro-biofactory” and drug delivery system. By secreting immunomodulatory and trophic factors once injected into the peritoneal cavity of dystrophic mice [3], they can ameliorate muscle morphology and function. Since the manipulation of the microcapsules is rather complicated, we performed for the first time, an ultrastructure study on SeC-MC. The good cell morphology, along with viability of organellar compartment, was demonstrated.