Vol 121, No 1 (2016)
Original Article

Osteoimmunology represents a link between skeletal and immune system

Published 2016-06-03


  • Osteoimmunology,
  • RANKl,
  • RANK,
  • Bone

How to Cite

Nicolin, V., De Iaco, D., & Valentini, R. (2016). Osteoimmunology represents a link between skeletal and immune system. Italian Journal of Anatomy and Embryology, 121(1), 37–42. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/1546


There is a complex interplay between the cells of the immune system and bone. These interactions are not only mediated by the release of cytokines and chemokines but also by direct cell–cell contact. Studies of intracellular signaling mechanisms in osteoclasts have revealed that numerous immunomodulatory molecules are involved in the regulation of bone metabolism. Recently, it was proposed that immunoreceptors found in the immune cells are also an essential signal for osteoclasts activation, along with receptor activator of NF-κB (RANK) ligand (RANKL). Collectively, these and similar observations regarding cross-regulation between the immune and skeletal systems constitute the field of osteoimmunology. Here we briefly highlight core areas of interest and selected recent advances in this field.