Vol. 126 No. 2 (2022)
Original Article

Presepsin assessment in maxillo-facial infections: a new early biomarker of sepsis?

Luigi Falconio
Department of Innovative Technologies in Medicine & Dentistry, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti
Oriana Trubiani
Department of Innovative Technologies in Medicine & Dentistry, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti
Diego Gazzolo
Neonatal Intensive Care Unit, Department of Pediatrics, University G. d’Annunzio, 65100 Chieti
Francesco Valente
Department of Innovative Technologies in Medicine & Dentistry, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti
Tonino Traini
Department of Innovative Technologies in Medicine & Dentistry, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti
Published December 27, 2022
Keywords
  • sepsis,
  • dentistry,
  • presepsin,
  • odontology infection
How to Cite
Falconio, L., Trubiani, O., Gazzolo, D., Valente, F., & Traini, T. (2022). Presepsin assessment in maxillo-facial infections: a new early biomarker of sepsis?. Italian Journal of Anatomy and Embryology, 126(2), 55-58. https://doi.org/10.36253/ijae-13797

Abstract

Odontogenic infections can cause serious inflammatory problems of the soft and hard tissues in the maxillofacial area up to, albeit in quite remote circumstances, involvement of the brain tissues. In recent years, therefore, a holistic diagnostic-therapeutic approach has been developed in the management of odontogenic infections by carrying out a careful systemic history of the patient who has an infectious condition in the oral cavity. The early detection of systemic sepsis conditions was facilitated using serum biomarkers such as PCR, Procalcitonin (PCT) and Presepsin (PSEP) in hospital emergency rooms. However, even if used in combination, their diagnostic accuracy is such as to suggest the importance of researching new, more specific, and sensitive biomarkers. A total of 9 articles was analyzed to investigate the use of the PSEP as biomarker in the maxillo-facial region infections and including only English-language articles and the electronic search of publications from 1 January 2017 to 31 December 2021. This study aimed to determine the diagnostic value of presepsin in condition of sepsis derived from an odontogenic infection and to evaluate its use in the prognostic evaluation phase of surgical interventions performed in the maxillofacial area.

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