The effects of micro-grafts in the treatment of androgenetic alopecia
- Androgenetic alopecia,
- autologous micro-grafts,
- morphological evaluations,
- hair restoration
Copyright (c) 2018 Gabriele Ceccarelli, Laura Benedetti, Flavio Lorenzo Ronzoni, Maurilio Sampaolesi, Letizia Trovato, Antonio Graziano, Ciro De Sio, Gabriella Cusella
This work is licensed under a Creative Commons Attribution 4.0 International License.
Androgenetic alopecia (AGA) is a hereditary androgen-dependent, progressive thinning of scalp hair affecting 60–70% of the adult population worldwide . In AGA, hair is lost in a well-defined pattern, beginning above both temples. Over time, hairline recedes to form a char- acteristic “M” shape. Pharmacological treatment offers moderate results and hair transplanta- tion represents the only permanent treatment option . Here we describe a clinical approach, based on autologous micro-grafts, called Rigenera® that is able to restore hair loss using a promising CE-certified medical device called Rigeneracons. Its efficacy was demonstrated in the wound care including the management of chronic or non-healing wounds and for hard tis- sues and cartilage regeneration . A preliminary in vivo study on three patients reported that autologous micro-grafts obtained by Rigenera® protocol promote hair growth even two months after the surgical procedure. The aim of this study was to demonstrate long-term efficacy of Rigenera® protocol in the treatment of AGA performing histological evaluations on scalps after 6 and 9 months from micro-grafts application with respect to controls. Morphological evalua- tions were performed by Haematoxylin/Eosin and Mallory Trichrome staining on 4-mm punch of scalps from volunteers patients. Results showed that, after 6 months of micro-grafts applica- tion, the number of hair follicles in the scalp is increased with a beginning of cuticle forma- tion and dermal papilla in proliferation. After 9 months, we reported a well-organized derma,more regular and structured collagen fibres, and hair follicles in Anagen IV/Mesanagen phase. In summary, micro-grafts application improve hair restoration with a positive patient’s subjec- tive assessment.
This work was supported by grant from NATO 2016 (“RAWINTS” G-984961): RApid Skin Wound healing by INtegrated Tissue engineering and Sensing).