Vol. 123, No. 1 (Supplement) 2018
Supplement abstract

The effects of micro-grafts in the treatment of androgenetic alopecia

Gabriele Ceccarelli
Università degli Studi di Pavia, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense e Centre for Health Technologies, Pavia, Italia
Laura Benedetti
Università degli Studi di Pavia, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense e Centre for Health Technologies, Pavia, Italia
Flavio Lorenzo Ronzoni
Università degli Studi di Pavia, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense e Centre for Health Technologies, Pavia, Italia
Maurilio Sampaolesi
Università degli Studi di Pavia, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense e Centre for Health Technologies, Pavia, Italia
Letizia Trovato
HBW, Human Brain Wave s.r.l, Torino, Italia
Antonio Graziano
HBW, Human Brain Wave s.r.l, Torino, Italia
Ciro De Sio
Private Practice, Specialist in Plastic Surgery, Roma, Italia
Gabriella Cusella
Università degli Studi di Pavia, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense e Centre for Health Technologies, Pavia, Italia
Published December 30, 2018
Keywords
  • Androgenetic alopecia,
  • autologous micro-grafts,
  • morphological evaluations,
  • hair restoration
How to Cite
Ceccarelli, G., Benedetti, L., Ronzoni, F. L., Sampaolesi, M., Trovato, L., Graziano, A., De Sio, C., & Cusella, G. (2018). The effects of micro-grafts in the treatment of androgenetic alopecia. Italian Journal of Anatomy and Embryology, 123(1), 57. https://doi.org/10.13128/ijae-11355

Abstract

Androgenetic alopecia (AGA) is a hereditary androgen-dependent, progressive thinning of scalp hair affecting 60–70% of the adult population worldwide [1]. In AGA, hair is lost in a well-defined pattern, beginning above both temples. Over time, hairline recedes to form a char- acteristic “M” shape. Pharmacological treatment offers moderate results and hair transplanta- tion represents the only permanent treatment option [2]. Here we describe a clinical approach, based on autologous micro-grafts, called Rigenera® that is able to restore hair loss using a promising CE-certified medical device called Rigeneracons. Its efficacy was demonstrated in the wound care including the management of chronic or non-healing wounds and for hard tis- sues and cartilage regeneration [3]. A preliminary in vivo study on three patients reported that autologous micro-grafts obtained by Rigenera® protocol promote hair growth even two months after the surgical procedure. The aim of this study was to demonstrate long-term efficacy of Rigenera® protocol in the treatment of AGA performing histological evaluations on scalps after 6 and 9 months from micro-grafts application with respect to controls. Morphological evalua- tions were performed by Haematoxylin/Eosin and Mallory Trichrome staining on 4-mm punch of scalps from volunteers patients. Results showed that, after 6 months of micro-grafts applica- tion, the number of hair follicles in the scalp is increased with a beginning of cuticle forma- tion and dermal papilla in proliferation. After 9 months, we reported a well-organized derma,more regular and structured collagen fibres, and hair follicles in Anagen IV/Mesanagen phase. In summary, micro-grafts application improve hair restoration with a positive patient’s subjec- tive assessment.

This work was supported by grant from NATO 2016 (“RAWINTS” G-984961): RApid Skin Wound healing by INtegrated Tissue engineering and Sensing).

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