Vol. 115 No. 1/2 (2010)
Original Article

The many faces of S100B protein: when an extracellular factor inactivates its own receptor and activates another one

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  • Guglielmo Sorci,
  • Francesca Riuzzi,
  • Cataldo Arcuri,
  • Roberta Bianchi,
  • Flora Brozzi,
  • Claudia Tubaro,
  • Ileana Giambanco,
  • Rosario Donato

Published 2010-09-07

Keywords

  • S100B,
  • proliferation,
  • differentiation,
  • RAGE,
  • FGFR1

How to Cite

Sorci, G., Riuzzi, F., Arcuri, C., Bianchi, R., Brozzi, F., Tubaro, C., Giambanco, I., & Donato, R. (2010). The many faces of S100B protein: when an extracellular factor inactivates its own receptor and activates another one. Italian Journal of Anatomy and Embryology, 115(1/2), 147–151. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/1073
Copyright Notice

Abstract

The Ca2+-binding protein of the EF­hand type, S100B, is an intracellular regulator and an extracellular signal. Within cells S100B interacts with several proteins thereby regulating energy metabolism, Ca2+ homeostasis, protein phosphorylation and degradation, and cell locomotion, proliferation and differentiation. Once secreted/released, S100B exerts autocrine and paracrine effects on responsive cells by engaging the receptor for advanced glycation end products. However, recent evidence suggests that S100B might also activate basic fibroblast growth factor receptor 1 via prior binding to basic fibroblast growth factor.
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