Vol 118, No 2 (Supplement) 2013
Supplement abstract

Influence of aging on peripheral nervous system: a morphological and morphometric study

Published 2014-01-13


  • aging,
  • peripheral nervous system,
  • morphometric analysis

How to Cite

Marmiroli, P., Canta, A., Buccomino, S., Meregalli, C., Sala, B., Bossi, M., & Cavaletti, G. (2014). Influence of aging on peripheral nervous system: a morphological and morphometric study. Italian Journal of Anatomy and Embryology, 118(2), 135. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/3792


It is well known that aging influences several functional and structural features of peripheral nerves (Verdù et al., 2000; Ceballos et al., 1999; Jeronimo et al., 2008). However, the role of these changes in the damage/repair mechanisms occurring in acquired peripheral neuropathies is still unclear. To this aim, a multimodal, long-term assessment in a mice model would represent an optimal tool to perform experimental neuropathy studies designed to evaluate the role of aging in relationship with a given nerve injury. In this study we used 40 females one-month-old C57B1/6 mice and we followed-up them for fifteen months. Digital and caudal nerve conduction velocity (NCV) studies were performed monthly to evaluate changes in electrophysiological features; moreover, four animals were sacrificed every two months in order to collect caudal nerve, sciatic nerve, dorsal root ganglia (DRG) and skin for morphological and morphometric analysis. The neurophysiological assessments showed a remarkable increase of caudal NCV until the age of 9 months and then it remained unchanged until the end of the observation period; in the same period, digital NCV increase was also present although less marked. At the pathological level, both caudal and sciatic nerves showed a decrease in fibres density related with age, whereas axon and fibres diameters tended to increase. These preliminary data can be considered a first step aiming at creating a background for future studies on the relationship between aging and peripheral nervous system induced damage.