Vol 118, No 1 (Supplement) 2013
Original Article

Acute treatment with relaxin attenuates the injury/ dysfunction induced by renal ischemia/reperfusion injury

Published 2014-01-11

Keywords

  • relaxin,
  • ischemia/reperfusion,
  • kidney,
  • inflammation

How to Cite

Collino, M., Rogazzo, M., Pini, A., Benetti, E., Rosa, A. C., Fantozzi, R., Bani, D., & Masini, E. (2014). Acute treatment with relaxin attenuates the injury/ dysfunction induced by renal ischemia/reperfusion injury. Italian Journal of Anatomy and Embryology, 118(1), 74–76. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/3275

Abstract

Although preclinical and clinical studies have demonstrated that relaxin (RLX) ameliorates impaired renal function by exerting antifibrotic and regenerative effects, its role in renal ischemia/reperfusion (I/R) injury has never been investigated. Using a well-known rat model of 1h bilateral renal artery occlusion followed by 6 h reperfusion, we investigated the effects of human recombinant RLX (5 μg /Kg e.v.) given both at the beginning and after 3 h reperfusion. Serum and urinary indicators of renal injury and dysfunction were measured. Interestingly, administration of the exogenous RLX attenuated all markers of renal injury and dysfunction caused by I/R. Overall, we document here, for the first time, that RLX protects against I/R-induced renal injury and dysfunction. The results of this study offer good perspectives for the clinical potential of RLX in the medical treatment of renal diseases.