Vol 118, No 1 (Supplement) 2013
Original Article

Relaxin and the control of primate parturition

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  • Gerson Weiss

Published 2014-01-11

Keywords

  • relaxin,
  • primate,
  • pregnancy

How to Cite

Weiss, G. (2014). Relaxin and the control of primate parturition. Italian Journal of Anatomy and Embryology, 118(1), 17–18. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/3207
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Abstract

In primate pregnancy, circulating relaxin, solely a product of the corpus luteum, peaks in the first trimester of pregnancy then declines and levels off for the remainder of pregnancy. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix. Relaxin, from early pregnancy, increases endometrial natural killer cells, macrophages and neutrophils, blood flow and arterial number. Hyperrelaxinemia correlates with preterm birth.

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