Vol 119, No 1 (Supplement) 2014
Supplement abstract

Human endothelial progenitor cells express a functional TRPV4 channel

Published 2015-03-19


  • Endothelial progenitor cells,
  • transient receptor potential channels,
  • SOCE,
  • vascular remodeling

How to Cite

Guerra, G., Dragoni, S., Poletto, V., Florio Pla, A., Cinelli, M., Tafuri, D., Laforenza, U., Munaron, L., Rosti, V., Montagnani, S., & Moccia, F. (2015). Human endothelial progenitor cells express a functional TRPV4 channel. Italian Journal of Anatomy and Embryology, 119(1), 101. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/2454


Endothelial progenitor cells (EPCs) are mobilized into circulation to replace damaged endothelial and recapitulate the vascular network of injured tissues (Moccia F et al., 2014). Intracellular Ca(2+) signals are key to EPC activation, but it is yet to be elucidated whether they are endowed with the same blend of Ca(2+) –permeable channels expressed by mature endothelial cells. For instance, endothelial colony forming cells (ECFCs), the only EPC subset truly committed to acquire a mature endothelial phenotype, lack canonical transient receptor potential channels 3, 5 and 6 (TRPC3, 5 and 6), which are widely distributed in vascular endothelium; on the other hand, they express a functional store-operated Ca(2+) entry (SOCE). The present study was undertaken to assess whether human circulating EPCs possess TRP vanilloid channel 4 (TRPV4), which plays a master signalling role in mature endothelium, by controlling both vascular remodelling and arterial pressure. W e found that EPCs express both TRPV4 mRNA and protein indicating that human circulating EPCs possess a functional TRPV4 protein before their engraftment into nascent vessels (Dragoni et al., 2014).