Vol. 127 No. 2 (2023)
Original Article

Reprogramming methods for induced pluripotent stem cells generation

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  • Ylenia Della Rocca,
  • Antonella Mazzone,
  • Jacopo Pizzicannella,
  • Guya Diletta Marconi ,
  • Oriana Trubiani,
  • Francesca Diomede
Ylenia Della Rocca
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini, 31, 66100 Chieti
Antonella Mazzone
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini, 31, 66100 Chieti
Jacopo Pizzicannella
Department of Engineering and Geology, University “G. d’ Annunzio” Chieti-Pescara, Viale Pindaro, 42, 65127 Pescara
Guya Diletta Marconi
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini, 31, 66100 Chieti
Oriana Trubiani
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini, 31, 66100 Chieti
Francesca Diomede
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini, 31, 66100 Chieti
DOI: https://doi.org/10.36253/ijae-14702

Published 2023-12-31

Keywords

  • embryonic stem cells,
  • pluripotency,
  • human ESC,
  • reprogramming

How to Cite

Della Rocca, Y., Mazzone, A., Pizzicannella, J., Marconi , G. D., Trubiani, O., & Diomede, F. (2023). Reprogramming methods for induced pluripotent stem cells generation. Italian Journal of Anatomy and Embryology, 127(2), 89–93. https://doi.org/10.36253/ijae-14702

Copyright (c) 2023 Ylenia Della Rocca, Antonella Mazzone, Jacopo Pizzicannella, Guya Diletta Marconi , Oriana Trubiani, Francesca Diomede

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Regenerative medicine expects to replace the function of tissue or organs damaged by disease, trauma, or congenital issues. The tools used to realize these outcomes are tissue engineering and cellular therapies. Cellular therapy is considered a regenerative medicine strategy based on the use of stem cells. Pluripotent stem cells are the hotspots of cellular therapy due to their features that have been showed promising results. Embryonic stem cells (ESCs) are pluripotent, self-renewing cells that are derived from the inner cell mass (ICM) of the developing blastocyst. Pluripotency is the main feature that lead single cell to generate all cell lineages of the developing and adult organism. The use of human ESC (hESC) is ethically controversial, to overcome this problem the induced pluripotent stem cells (iPSCs) were developed. The aim of the present mini-review is to report a comprehensive summary of the different cellular reprogramming techniques from its initial conception to the present day.

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