Vol. 127 No. 2 (2023)
Original Article

Modulation of inflammatory pathway in human gingival fibroblasts exposed to resinous materials

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  • Antonella Mazzone,
  • Ylenia Della Rocca,
  • Jacopo Pizzicannella,
  • Francesca Diomede,
  • Guya Diletta Marconi,
  • Oriana Trubiani
Antonella Mazzone
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti
Ylenia Della Rocca
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti
Jacopo Pizzicannella
Department of Engineering and Geology, University “G. d’ Annunzio” Chieti-Pescara, Viale Pindaro, 42, 65127 Pescara
Francesca Diomede
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti
Guya Diletta Marconi
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti
Oriana Trubiani
Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti
DOI: https://doi.org/10.36253/ijae-14694

Published 2023-12-31

Keywords

  • hGFs,
  • ProTemp 4™,
  • Coldpac,
  • inflammation,
  • biocompatibility

How to Cite

Mazzone, A., Della Rocca, Y., Pizzicannella, J., Diomede, F., Marconi, G. D., & Trubiani, O. (2023). Modulation of inflammatory pathway in human gingival fibroblasts exposed to resinous materials. Italian Journal of Anatomy and Embryology, 127(2), 77–82. https://doi.org/10.36253/ijae-14694

Copyright (c) 2023 Antonella Mazzone, Ylenia Della Rocca, Jacopo Pizzicannella, Francesca Diomede, Guya Diletta Marconi, Oriana Trubiani

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The goal of this work was to evaluate the anti-inflammatory effects of two resins, Bis-GMA-based resin (ProTemp 4™) and PMMA-based resin (Coldpac), used in dentistry for temporary prosthetics treatments, in the modulation of the inflammatory pathway NFkBp65/NLRP3/IL-1β. The protein expression of inflammatory markers was evaluated in an in vitro model of primary human gingival fibroblasts (hGFs) by immunofluorescence analysis while the study of the ultra-morphological analysis was performed through scanning electron microscopy. Taken together these results may suggest that ProTemp 4™ resin exerts a better performance in terms of inflammatory modulation.

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