Vol. 124 No. 3 (2019)
Original Article

Structure, morphology and signalling development mechanisms of human salivary glands

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  • Margherita Sisto,
  • Domenico Ribatti,
  • Sabrina Lisi
Margherita Sisto
Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari “Aldo Moro”, Bari, Italy
Domenico Ribatti
Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari “Aldo Moro”, Bari, Italy
Sabrina Lisi
Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari “Aldo Moro”, Bari, Italy
DOI: https://doi.org/10.13128/ijae-11659

Published 2020-05-20

Keywords

  • Salivary gland development,
  • acinar cells,
  • ductal cells,
  • myoepithelial cells,
  • branching morphogenesis,
  • EGF,
  • FGF
    • ...More
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How to Cite

Sisto, M., Ribatti, D., & Lisi, S. (2020). Structure, morphology and signalling development mechanisms of human salivary glands. Italian Journal of Anatomy and Embryology, 124(3), 305–318. https://doi.org/10.13128/ijae-11659
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Abstract

The human salivary gland (SGs) develops as a highly branched structure designed to produce and secrete saliva indispensable to maintain the health of the oral cavity and for carry out physiological functions like mastication, taste perception and speech. Here we review the anatomy and cytoarchitecture of SGs and the most recent literature that has enabled a better understanding of the molecular signalling pathways of SGs development to translate this basic research towards therapy for patients suffering from salivary hypo function.

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