Vol. 123, No. 1 (Supplement) 2018
Supplement abstract

Effects of a tart cherry enriched diet on obese rats brain

Daniele Tomassoni
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italia
Seyed Khosrow Tayebati
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Ilenia Martinelli
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Michele Moruzzi
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Consuelo Amantini
School of Biosciences and Veterinary Medicines, University of Camerino, Camerino, Italia
Maria Vittoria Micioni di Bonaventura
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Maria Elena Giusepponi
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Carlo Polidori
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Giulio Lupidi
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Gabriella Gabrielli
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italia
Carlo Cifani
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia
Francesco Amenta
School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italia

Published 2018-12-30

Keywords

  • Obesity,
  • high-fat diet,
  • brain damage,
  • antioxidants,
  • tart cherries

How to Cite

Tomassoni, D., Tayebati, S. K., Martinelli, I., Moruzzi, M., Amantini, C., Micioni di Bonaventura, M. V., Giusepponi, M. E., Polidori, C., Lupidi, G., Gabrielli, G., Cifani, C., & Amenta, F. (2018). Effects of a tart cherry enriched diet on obese rats brain. Italian Journal of Anatomy and Embryology, 123(1), 218. https://doi.org/10.13128/ijae-11545

Abstract

Increased food intake, reduced physical activity, and altered metabolic processes are the variables that affect energy balance inducing obesity. High Body Mass Index is associated with the development of cardiovascular risk factors such as hypertension, dyslipidemia, insulin resistance and diabetes mellitus leading to cardiovascular and cerebrovascular diseases promot- ing cognitive decline. Obesity has been suggested as a risk factor for Alzheimer’s disease and vascular dementia and has been associated with poorer cognitive performance in population- based studies. Evidence suggests that overconsumption of high-energy foods and the associ- ated obesity negatively influence brain function. This study has evaluated the potential effects of tart cherries (Prunus Cerasus L.) on the brain rats with Diet-Induced Obesity (DIO). They were fed for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice (DJS). DIO rats were compared to the control rats feed with standard diet (CHOW). Food consumption, body and fat mass weight, fasting glycemia, insulin, cholesterol, and triglycerides levels were measured. Immunochemi- cal, immunohistochemical and qRT-PCR techniques were used to determine neuronal andglial alterations. No differences in body weight were found in treated rats compared to con- trol group. In DS and DJS a decrease of blood pressure and glycemia and of serum levels of thiobarbituric reactive substances were found. Glial fibrillary acid protein expression decreased in the hippocampus and in the frontal cortex of treated rats. A reduction of microglial activa- tion was also found. Moreover, neurofilament increased in treated rats compared to DIO. Tart cherries did not modify synaptic protein and TRP channels expression in DIO rats. Vascular tree and blood-brain barrier were also affected in DIO rats, with modulation in DS and DJS. These findings indicate that tart cherries, although did not affect body weight values prevent the development of related risk factors. In the brain tart cherries reduced inflammation. The results may represent the first step to clarify the possible use of tart cherries supplementation to prevent obesity-induced brain damage. Further studies are needed to better understand the specific mechanisms of action of tart cherry components.

Acknowledgment. This study was supported by a Grant of University of Camerino.

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