Vol. 123, No. 1 (Supplement) 2018
Supplement abstract

Role of autophagy in T regulatory cells (Tregs)- polarization during atherosclerosis disease

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  • S. Mandatori,
  • D. Starace,
  • S. Piconese,
  • I. Pacella,
  • M. Caprio,
  • A. Armani,
  • V. Marzolla,
  • C. Mammi,
  • F. Padula,
  • E. Ziparo,
  • F. Cecconi,
  • A. Filippini
S. Mandatori
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome
D. Starace
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of RomeD
S. Piconese
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome
I. Pacella
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome
M. Caprio
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy. Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy
A. Armani
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.
V. Marzolla
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.
C. Mammi
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.
F. Padula
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome
E. Ziparo
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome
F. Cecconi
Department of Biology, University of Rome Tor Vergata, Rome, Italy. Department of PaediatricHaematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy. Unit of Cell Stress and Survival, Danish Cancer Society Research Center, Copenhagen, Denmark.
A. Filippini
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome
DOI: https://doi.org/10.13128/ijae-11439

Published 2018-12-30

Keywords

  • Tregs,
  • autophagy,
  • atherosclerosis,
  • ApoEKO

How to Cite

Mandatori, S., Starace, D., Piconese, S., Pacella, . I., Caprio, M., Armani, A., Marzolla, V., Mammi, C., Padula, F. ., Ziparo, E. ., Cecconi, . F., & Filippini, A. (2018). Role of autophagy in T regulatory cells (Tregs)- polarization during atherosclerosis disease. Italian Journal of Anatomy and Embryology, 123(1), 132. https://doi.org/10.13128/ijae-11439
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Abstract

Atherosclerosis is a chronic inflammatory disorder of the large arteries and represents the primary cause of heart disease and stroke. The exact cause of atherosclerosis is not known. A variety of studies show that autophagy deficiency may be pro-atherogenic and the role of autophagy in smooth muscle cells, macrophages and endothelial cells has been investigated [1]. However, to date no studies addressed the effect of autophagy on leukocyte subsets play- ing a role in plaque formation and development. The presentproject aims to better clarify the role played by autophagy in lymphocyte homeostasis in human atherosclerotic plaques and in APOE-KO, a mouse model of atherogenesis [2]. In particular, we will investigate cell-autono- mous autophagy in mouse Tconv/Tregfunctions, evaluate autophagy-driven T cell polarization in stabilizing atherosclerotic plaques in a mouse model mouse of atherosclerosis. The compre- hension of the role of autophagy as a further mechanism underlying Treg induction and stabil- ity may open new therapeutic avenues for atherosclerosis.

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