Vol. 115 No. 1/2 (2010)
Original Article

Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?

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  • Franco Fais,
  • Silvia Bruno,
  • Fabio Ghiotto

Published 2010-09-07

Keywords

  • immunoglobulin variable region,
  • chronic lymphocytic leukemia

How to Cite

Fais, F., Bruno, S., & Ghiotto, F. (2010). Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?. Italian Journal of Anatomy and Embryology, 115(1/2), 79–84. Retrieved from https://oajournals.fupress.net/index.php/ijae/article/view/1062
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Abstract

The past 15 years have witnessed an enormous effort in studying B-cell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease.
This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the B-cell receptor (BcR) of the leukemic clones. These stud­ ies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/expansion and underscore the informative value represented by BcR analyses.
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