Vol. 127 No. 2 (2023)
Original Article

Effects of temperature on presepsin assessment in biological fluids

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  • Valentina Botondi,
  • Ebe D'Adamo,
  • Oriana Trubiani,
  • Diego Gazzolo
Valentina Botondi
Neonatal Intensive Care Unit, G. d’Annunzio University, Chieti
Ebe D'Adamo
Neonatal Intensive Care Unit, G. d’Annunzio University, Chieti
Oriana Trubiani
2Department of Innovative Technologies in Medicine & Dentistry, University “G. D’Annunzio”, Chieti
Diego Gazzolo
Neonatal Intensive Care Unit, G. d’Annunzio University, Chieti
DOI: https://doi.org/10.36253/ijae-14690

Published 2023-12-31

Keywords

  • presepsin,
  • temperature,
  • biological fluids,
  • sample storage

How to Cite

Botondi, V., D’Adamo, E., Trubiani, O., & Gazzolo, D. (2023). Effects of temperature on presepsin assessment in biological fluids. Italian Journal of Anatomy and Embryology, 127(2), 69–72. https://doi.org/10.36253/ijae-14690

Copyright (c) 2023 Valentina Botondi, Ebe D'Adamo, Oriana Trubiani, Diego Gazzolo

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Thermal stabilization is important for assuring a sample quality and prevent protein denaturation. Presepsin is a new reliable biomarker of sepsis produced in response to bacterial infections. However, before its inclusion into clinical practice several criteria need to be fulfilled. One of these regards the samples thermostability after a long-term refrigeration in different biological fluids (blood, urine, saliva) that can constitute a confounding factor for Presepsin reliability as diagnostic test. On this light, this review offers an update of studies analyzing presepsin after sample thawing.

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